Skip to main content
. 2022 Mar 14;13:1299. doi: 10.1038/s41467-022-28931-3

Fig. 1. Beneficial substitutions for hMPV F stabilization.

Fig. 1

a Schematic of the hMPV F ectodomain. Disulfide bonds and N-linked glycosylation sites are highlighted. The residue numbers indicating the beginning and the end of the F1 and F2 subunits are shown. b Side view of the trimeric hMPV F ectodomain in a prefusion conformation (PDBID: 5WB0). One protomer is shown as a ribbon diagram, and the other two are shown as a white molecular surface. Insets highlight the position of select stabilizing substitutions. Side chains in each inset are shown as dark red sticks with sulfur atoms in yellow, nitrogen atoms in blue and oxygen atoms in red. In both panels, regions undergoing conformational changes during the pre-to-postfusion transition are colored blue and the regions remaining static are colored green.