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. 2022 Mar 14;13:1299. doi: 10.1038/s41467-022-28931-3

Fig. 4. Crystal structure of engineered hMPV F variant DSx2 bound to antibody MPE8.

Fig. 4

a Side view of the atomic model of hMPV F variant DSx2 bound to MPE8 Fab, shown as ribbons. The F protomer is colored green, the heavy chain of MPE8 is colored purple and the light chain of MPE8 is colored white. The constant region of MPE8 Fab is omitted for clarity. Side chains of two disulfide substitutions in DSx2 are highlighted as sticks. b Zoomed view of the binding interface of the MPE8 light chain CDRs and F antigenic sites II and V. c Zoomed view of the binding interface of the MPE8 heavy chain CDRs and F. Main chain atoms of H-CDR3 pack against antigenic site III, which is highlighted as a transparent surface. Key residues that form polar interactions are shown as sticks.