Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 14;13:1327. doi: 10.1038/s41467-022-28775-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 3 — a UMAP plot showing unsupervised subclustering of E18.5 and adult femoral ECs. Bar charts indicate percentage of each subcluster. Cell numbers are shown on the right. b UMAP plots showing distribution of representative markers for each EC subcluster. Color represents relative gene expression level. c DEGs for E18.5 and adult EC subclusters. Blue dots, p-adjusted value < 0.001; Red dots, p-adjusted value < 0.001 and Log₂ fold change >1. Two-tailed Student’s t test. d Violin plots showing expression of selected EC-derived HSPC-supporting factors at E18.5 or in adult with log normalized values (y axis). e, f Interactome analysis of potential interactions (arrows) between non-haematopoietic supportive cells and HSPCs (e) or multipotent HSPCs (f). Width of line and arrow represent relative log2 fold change of genes. Cyan arrows indicate signaling enriched in adult; red arrows show enrichment at E18.5.