Fig. 2.
The RyR2 macromolecular complex. Schematic of the ryanodine receptor type 2 (RyR2) Ca2+ channel and its associated proteins which together comprise the RyR2 macromolecular complex, localised to the junctional sarcoplasmic reticulum (SRJ) membrane. Cytosolic accessory proteins include calmodulin (CaM), Ca2+/CaM-dependent kinase II (CaMKII), FK506-binding protein (FKBP) 12.6, protein kinase A (PKA), protein phosphatases PP1 and PP2A, and sorcin. PKA interaction with RyR2 is facilitated via the muscle-specific A-kinase anchoring protein (mAKAP). Luminal accessory proteins include junctin and triadin which mediate the interaction of calsequestrin-2 (CSQ2). These three luminal proteins make the quaternary protein complex with RyR2. Created with BioRender.com