Table 1.

Diversity of membrane lipid species documented for the ESKAPE pathogens

Bacterial species	Major membrane lipid species	References
E. faecium	PG, CL, Lysyl-PG, GP-DGDAG, Type I LTA, FA	Mishra et al. 2012; Theilacker et al. 2012)
S. aureus	PG, CL, Lyso-PG, GPL, Lysyl-PG, Type I LTA, FA	Epand and Epand 2009a; Song et al. 2020; Schneewind and Missiakas 2014; Kilelee et al. 2010; Malanovic and Lohner 2016; Oku et al. 2004; White and Frerman 1967)
K. pneumoniae	PG, PE, CL, SL, PC, Lysyl-PG, Lyso-PE, PI, PA, Lyso-PA, Lyso-PC, LPS, FA	Epand and Epand 2009a; Jasim et al. 2018; Vinogradov et al. 2002; Hobby et al. 2019)
A. baumannii	PE, PG, CL, Lyso-PE, Acyl-PG, PA, MLCL, PE-OH, CL-OH, MLCL-OH, LPS, FA	Jiang et al. 2019a; Unno et al. 2017; Jiang et al. 2020; Lopalco et al. 2017)
P. aeruginosa	PG, CL, PE, PC, OL, Alanyl-PG, RL, LPS, FA	Epand and Epand 2009a; Malanovic and Lohner 2016; Chao et al. 2010; Lam et al. 2011; Klein et al. 2009; Lewenza et al. 2011; Pramanik et al. 1990; Wilderman et al. 2002; Soberón-Chávez et al. 2005)
Enterobacter species† (E. cloacae, E. hormaechei, and E. aerogenes)	PG, PE, CL, LPS, FA	Epand and Epand 2009a; Bøse and Gjerde 1980; Gill and Suisted 1978; Kämpfer et al. 2015; Davin-Regli et al. 2019; Epand and Epand 2009b; Epand et al. 2010)

^†As there are 22 species found in the Enterobacter genus, only common species described in nosocomial infections were analysed and lipid compositions are assumed to be similar between each (same genus)(Davin-Regli et al. 2019; Epand et al. 2010; Villegas and Quinn 2002)

^*See Supplementary Information (Sects. 1 and 2) for bacterial and lipid species acronym definitions, respectively