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. 2022 Mar 1;12:818860. doi: 10.3389/fonc.2022.818860

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Copyright © 2022 Xu, Pei, Liu, Yu, Guo, Liu and Kang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Volcano plot of differentially expressed genes in BLCA from the TCGA database. (B) Consensus map clustered via the non-negative matrix factorization (NMF) algorithm. (C) The cophenetic correlation coefficient is used to reflect the stability of the cluster obtained from NMF. (D) RSS is used to reflect the clustering performance of the model. (E) Overall survival (OS) showed significant differences between C1 and C2. (F) Progression-free survival (PFS) showed significant differences between C1 and C2. (G) Alluvial plot showing the percentage of C1 and C2 between molecular subtypes.