Fig. 1.

Schematic overview of the radiomics approach: 

adapted from Vos et al. [24]. Input to the algorithm are the CT images (1). Processing steps then include segmentation of the tumor (2), feature extraction (3), and the creation of machine learning decision models (5), using an ensemble of the best 100 workflows from 1000 candidate workflows (4), which are different combinations of the different processing and analysis steps (e.g., the classifier used). *Abbreviations: GIST, gastrointestinal stromal tumor; MI, mitotic index