Table 1.

Pharmacokinetic parameters (mean ± SD) of florfenicol following oral administration (15 mg/kg) at two temperatures and two salinities (n = 4 for the 32°C with 15 ppt group; n = 7 for the other three groups).

	24°C	32°C
Ka (1/h): Absorption rate constant
5 ppt	1.78 ± 0.69a, A	2.42 ± 0.16a, A
15 ppt	1.51 ± 0.56a, A	3.39 ± 2.20a, B
t1/2Ka (h): Absorption half-life
5 ppt	0.39 ± 0.14a, A	0.29 ± 0.02a, A
15 ppt	0.46 ± 0.20a, A	0.20 ± 0.11a, B
α (1/h): Distribution rate constant
5 ppt	1.25 ± 0.15a, A	2.13 ± 0.14a, B
15 ppt	1.20 ± 0.31a, A	1.73 ± 0.76a, A
t1/2α (h): Distribution half-life
5 ppt	0.56 ± 0.07a, A	0.32 ± 0.02a, B
15 ppt	0.58 ± 0.19a, A	0.40 ± 0.34a, A
β (1/h): Elimination rate constant
5 ppt	0.048 ± 0.007a, A	0.083 ± 0.011a, B
15 ppt	0.045 ± 0.003a, A	0.086 ± 0.009a, B
t1/2β (h): Elimination half-life
5 ppt	14.52 ± 1.95a, A	8.35 ± 0.09a, B
15 ppt	15.51 ± 1.16a, A	8.06 ± 0.82a, B
k12 (1/h): Transfer rate constant from the central (1) to peripheral (2) compartment
5 ppt	0.72 ± 0.13a, A	1.25 ± 0.14a, B
15 ppt	0.63 ± 0.32a, A	0.94 ± 0.54a, B
k21 (1/h): Transfer rate constant from the peripheral (2) to central (1) compartment
5 ppt	0.44 ± 0.09a, A	0.71 ± 0.06a, B
15 ppt	0.35 ± 0.11a, A	0.65 ± 0.16a, B
k10 (1/h): Elimination rate constant from the central compartment
5 ppt	0.14 ± 0.01a, A	0.25 ± 0.04a, B
15 ppt	0.13 ± 0.04a, A	0.22 ± 0.08a, B
Cmax (μg/mL): Maximum serum concentration
5 ppt	29.59 ± 4.63a, A	27.75 ± 2.96a, A
15 ppt	25.66 ± 2.36a, A	27.97 ± 2.59a, A
Tmax (h): Time to reach Cmax
5 ppt	0.95 ± 0.20a, A	0.60 ± 0.04a, B
15 ppt	1.15 ± 0.33a, A	0.61 ± 0.14a, B
AUC (h): Area under the serum concentration-time curve
5 ppt	423.28 ± 99.13a, A	233.00 ± 33.63a, B
15 ppt	393.40 ± 41.65a, A	235.66 ± 25.02a, B
Vc/F (L/kg): Volume of distribution of the central compartment relative to bioavailability
5 ppt	0.27 ± 0.06a, A	0.27 ± 0.04a, A
15 ppt	0.32 ± 0.11a, A	0.32 ± 0.12a, A
Vz/F (L/kg): Volume of distribution during the elimination phase relative to bioavailability
5 ppt	0.77 ± 0.11a, A	0.79 ± 0.11a, A
15 ppt	0.86 ± 0.09a, A	0.75 ± 0.03a, A
Vss/F (L/kg): Volume of distribution at steady-state relative to bioavailability
5 ppt	0.71 ± 0.09a, A	0.73 ± 0.10a, A
15 ppt	0.79 ± 0.08a, A	0.69 ± 0.03a, A
CL/F (L/kg/h): Clearance relative to bioavailability
5 ppt	0.037 ± 0.007a, A	0.066 ± 0.010a, B
15 ppt	0.039 ± 0.005a, A	0.064 ± 0.007a, B
MRT (h): Mean residence time
5 ppt	20.34 ± 2.61a, A	11.70 ± 1.53a, B
15 ppt	21.35 ± 1.66a, A	11.19 ± 1.19a, B

The means of half-lives are harmonic means whereas the means of the other PK parameters are arithmetic means. For each PK parameter, means with different small superscripts in each column and means with different capital superscripts in each row are significantly different from each other (p < 0.05).