Table 3.

Risk for dementia associated with APOE4.

	Events/person-years		Incidence rate*		HR (95% CI),	HR (95% CI),	HR (95% CI),
	Non-APOE4 Carriers	APOE4 carriers	Non-APOE4 carriers	APOE4 carriers	Model 1†	Model 2	Model 3
All-cause dementia
All	3281/4,155,062	2667/1,311,270	0·79	2·03	2·65 (2·52–2·79)	2·67 (2·54–2·81)	2·73 (2·59–2·87)
Young-onsetǂ	349/3,335,485	131/1,053,453	0·10	0·12	1·19 (0·97–1·45)	1·23 (1·00–1·50)	1·26 (1·03–1·54)
Late-onset§	2932/2,798,517	2536/874,175	1·05	2·90	2·83 (2·69–2·99)	2·85 (2·70–3·01)	2·90 (2·75–3·06)
AD
All	1172/4,161,795	1322/1,315,407	0·28	1·01	3·64 (3·37–3·94)	3·64 (3·36–3·93)	3·69 (3·41–4·00)
Young-onset	97/3,335,485	47/1,053,453	0·03	0·04	1·53 (1·08–2·17)	1·55 (1·09–2·20)	1·58 (1·11–2·24)
Late-onset	1075/2,798,517	1275/874,175	0·38	1·46	3·88 (3·58–4·21)	3·87 (3·57–4·20)	3·93 (3·62–4·27)
VD
All	758/4,162,776	565/1,317,422	0·18	0·43	2·41 (2·16–2·68)	2·45 (2·19–2·73)	2·52 (2·26–2·81)
Young-onset	56/3,335,485	20/1,053,453	0·02	0·02	1·14 (0·68–1·89)	1·19 (0·71–1·98)	1·27 (0·76–2·13)
Late-onset	702/2,798,517	545/874,175	0·25	0·62	2·55 (2·28–2·85)	2·60 (2·32–2·91)	2·67 (2·39–2·99)

AD, Alzheimer's disease; APOE4, apolipoprotein E4; CI, confidence interval; HR, hazard ratio; VD, vascular dementia.

^⁎Refers to number of cases per 1000 person-years.

^†Cox proportional hazard regression models were used to examine the association between APOE4 and incident dementia. Model 1 was adjusted for age and gender; Model 2 was adjusted for Model 1 plus education, income, BMI, smoking, physical activity, alcohol consumption, sleep duration, and diet; Model 3 was adjusted for blood pressure, HDL-C, LDL-C, triglycerides, and HbA1c.

^ǂYoung-onset dementia was defined as dementia diagnosed <65 years. The analysis was conducted among individuals aged younger than 65 years at baseline.

^§Late-onset dementia was defined as dementia diagnosed ≥65 years. The analysis was conducted among individuals aged older than 65 years at the end of follow-up.