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. 2022 Mar 1;12:846232. doi: 10.3389/fonc.2022.846232

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Copyright © 2022 Roehrkasse, Peterson, Fung, Pelargos and Dunn

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genomic landscape of meningiomas included in the cohort. (A) Depiction of all Grade 1 meningioma cases harboring high grade (red) or low grade (green) copy number profiles and sequence alterations as determined by advanced molecular profiling. (B) Plot showing copy number alterations and sequence alteration for all WHO grade 2 and 3 cases included in the study. For both (A, B) each vertical column represents one case. TERT mutations were in the promoter in 17% (1 case) of WHO Grade 1 meningiomas (A) and in all of the WHO grade 2 TERT mutated meningiomas (1 case) (B).