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. 2022 Jan 13;81(4):480–489. doi: 10.1136/annrheumdis-2021-220500

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Comparative overview of intermolecular bonds formed in the trimolecular complexes of TCR#16 and DRB1*04:01 (MHCII) associated with either (A) gal₂₆₄Col2 or (B) nCol2. Amino acids are shown in one letter code and their positions in the respective protein sequences indicated by number. Bold lines indicate salt bridges and dashed lines indicate hydrogen bonds. ai, aromatic interaction; bb, backbone; CDR, complementarity determining region; MHC, major histocompatibility complex; sc, side chain, TCR, T-cell receptor.