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. 2022 Jan 19;81(4):524–536. doi: 10.1136/annrheumdis-2021-220873

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Effect of mavrilimumab on inflammatory infiltrates in ex vivo cultured arteries from patients with GCA. (A) Immunofluorescence staining with anti-phospho-STAT5 antibody (green) of a GCA artery cultured with placebo or mavrilimumab. (B) Quantification of positive cells per field A; this experiment was performed three times with similar results. (C) mRNA Spl1/PU.1 transcripts in 11 cultured GCA-affected temporal arteries in the presence of placebo or mavrilimumab. (D) Transcript levels for cell markers CD3ε, CD20, CD14, CD16 and CD68 in 11 cultured GCA-involved temporal arteries exposed to placebo or mavrilimumab. (E) Quantification of cells per field that are positive for anti-CD16, anti-CD3Ɛ, anti-CD68, and anti-CD20. (F) Immunofluorescence staining of cultured GCA-involved arteries in the presence of placebo or mavrilimumab with anti-CD16, anti-CD3Ɛ, anti-CD68, and anti-CD20 (red colour) and DAPI (blue). Representative of 3 GCA cultured arteries. Panel E is the quantification of panel F. DAPI, 4′,6-diamidino-2-phenylindole; GCA, giant cell arteritis.