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. 2022 Jan 19;81(4):524–536. doi: 10.1136/annrheumdis-2021-220873

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Mavrilimumab impacts macrophage functions. (A) Transcript levels of IL-6 (left), TNFα (central) and IL-1β (right) in GCA-positive arteries (n=11) exposed to placebo or mavrilimumab (mRNA, relative units). IL-6, tumour necrosis factor α (TNFα) and IL-1β proteins (pg/mL) were also measured in GCA artery culture supernatants of the same samples. (B) CD206, CD163 and IL-10 mRNA transcript levels in the same GCA arteries exposed to mavrilimumab or placebo. IL-10 protein (pg/mL) was also detected in the supernatant (right panel). GCA, giant cell arteritis; IL, interleukin.