TABLE 2.
Differences in primary outcomes between intervention and control protocols at 12 and 24 wk post enrollment, disaggregated by risk group and for all children1
| High risk only | Low risk only | All enrolled children | ||||||
|---|---|---|---|---|---|---|---|---|
| Intervention (n = 317) | Control (n = 393) | Intervention (n = 256) | Control (n = 321) | Intervention (n = 573) | Control (n = 714) | Adjusted rd (95% CI)2 | P value | |
| 12-wk outcomes | ||||||||
| Recovered | 134 (42.3) | 143 (36.3) | 139 (54.3) | 135 (42.1) | 273 (47.6) | 278 (38.9) | 0.08 (0.04, 0.13) | <0.001 |
| Died | 4 (1.3) | 12 (3.1) | 6 (2.3) | 10 (3.2) | 10 (1.8) | 22 (3.1) | −0.02 (−0.03, −0.00) | 0.042 |
| Deteriorate to SAM by follow-up | 78 (24.6) | 126 (32.0) | 24 (9.4) | 52 (16.2) | 100 (17.5) | 174 (24.4) | −0.07 (−0.11, −0.04) | <0.001 |
| Remained with MAM | 89 (28.1) | 86 (21.8) | 73 (28.5) | 109 (34.0) | 162 (28.3) | 195 (27.3) | −0.01 (−0.06, 0.05) | 0.922 |
| Recent illness3 | 76 (24.0) | 90 (22.9) | 48 (18.8) | 80 (24.9) | 124 (21.6) | 170 (23.8) | −0.04 (−0.09, 0.02) | 0.170 |
| 24-wk outcomes | ||||||||
| Recovered | 115 (36.2) | 134 (34.1) | 134 (52.3) | 136 (42.3) | 249 (43.5) | 270 (37.8) | 0.06 (0.02, 0.11) | 0.007 |
| Died | 9 (2.8) | 20 (5.1) | 10 (3.9) | 17 (5.3) | 19 (3.3) | 37 (5.2) | −0.02 (−0.04, 0.00) | 0.057 |
| Deteriorate to SAM by follow-up | 127 (40.1) | 147 (37.4) | 45 (17.6) | 86 (26.8) | 178 (31.1) | 244 (34.2) | −0.03 (−0.09, 0.02) | 0.241 |
| Remained with MAM | 32 (10.1) | 30 (7.6) | 32 (12.5) | 44 (13.7) | 64 (11.2) | 74 (10.4) | 0.01 (−0.04, 0.05) | 0.744 |
| Relapsed4 | 16 (5.1) | 20 (5.1) | 14 (5.5) | 24 (7.5) | 30 (5.2) | 44 (6.2) | −0.01 (−0.04, 0.02) | 0.443 |
| Recent illness3 | 50 (18.3) | 69 (22.6) | 51 (19.9) | 69 (21.5) | 101 (20.7) | 138 (23.8) | −0.04 (−0.10, 0.01) | 0.151 |
1Values are n (%) or mean (95% CI) unless otherwise indicated. Outcomes were compared using logistic regression analysis (statistical comparison was not conducted for risk subgroups owing to the risk of being underpowered). MAM, moderate acute malnutrition; rd, risk difference; SAM, severe acute malnutrition.
2Rd adjusted for age and sex, and model accounted for clustering by clinic site.
3Diarrhea, rash, fever, or cough in the past 14 d.
4Developed MAM having previously recovered.