TABLE 5.

Association of penicillin susceptibility and variations of conserved motifs forming or surrounding active penicillin-binding proteins (PBPs) binding sites in PBP2x, PBP2b and PBP1a in S. pneumoniae isolates from CSF.

SIR	MIC (μg/ml)	No.	PBP2x				PBP2b		PBP1a
			T338	M339	H394	L546	T446	A619	T371	P432
PSSP	≤ 0.03	17
PRSP	0.25	1
	0.5	1				A		A	T
	0.5	2	A		V	A		S	T
	0.5	2	A			A
	1	1	A		V	A	G	A	T
	1	1	A		V	A	G	S	T
	1	6	A		V	A		S	T
	2	2	A	F	V	A		A	T
	2	6	A		V	A		A	T
	2	6	A	F	V	A	G	S	T
	2	3	A		V	A	G	S	T
	2	7	A		V	A		S	T
	4	1	A		V	A		A	T
	4	1	A		V	A	G	S	T

PSSP, penicillin-susceptible S. pneumoniae; PISP, penicillin-intermediate S. pneumoniae; PRSP, penicillin-resistant S. pneumoniae.