TABLE 6.

Association of penicillin susceptibility and variations of conserved motifs forming or surrounding active penicillin-binding proteins (PBPs) binding sites in PBP2x, PBP2b, PBP1a in S. pneumoniae isolates from non-CSF specimens.

SIR	MIC (μg/ml)	No.	PBP2x				PBP2b		PBP1a
			T338	M339	H394	L546	T446	A619	T371	P432
	≤ 0.12	82
	0.25	1					A
	0.25	5
PSSP	0.5	1	A	F		V	A		A	T
	0.5	5	A			V	A		A	T
	0.5	1			L		A		S
	0.5	1	A			V	A			T
	0.5	5	A				A
	0.5	1			L	V	A
	0.5	1			L		A
	0.5	6					A
	0.5	1	A			V
	0.5	1			L
	1	1	A	F		V	A		A	T
	1	6	A			V	A		A	T
	1	1	A	F		V	A		S	T
	1	15	A			V	A		S	T
	1	1	A			V	A	G
	2	1	A	F		V	A		A	T
	2	30	A			V	A		A	T
	2	1					A		A	T
	2	23	A	F		V	A	G	S	T
	2	25	A			V	A	G	S	T
	2	1					A	G	S	T
	2	16	A			V	A		S	T
	4	3	A	F		V	A	G	S	T
	4	6	A			V	A	G	S	T
PISP	4	1	A			V	A		S	T
	4	1	A	F		V	S	G	S	T

PSSP, penicillin-susceptible S. pneumoniae; PISP, penicillin-intermediate S. pneumoniae; PRSP, penicillin-resistant S. pneumoniae.