Skip to main content
. 2020 Mar 30;14(10):1462–1472. doi: 10.1093/ecco-jcc/jjaa065

Figure 3.

Figure 3.

Reg3 regulation by SCFAs. [A] Expression of Reg3B [left] and Reg3G [right] in small intestinal organoids after adding sodium propionate or sodium acetate to culture media. [B] Left, mRNA levels of GPR43 in small intestinal organoids after sodium propionate or sodium acetate treatment; right, Reg3B and Reg3G expression levels after SCFA treatment in small intestine organoids derived from GPR43-KO mice. [C] Caecum mRNA expression levels of Reg3B [left] and Reg3G [middle] in GF mice after oral treatment with propionate or in ASF gnotobiotic mice compared to GF controls [GF-CTR]; left, 1H-NMR analyses of propionate in caecal contents after propionate treatment or ASF colonization [n.d.: not detected/below level of detection]. Data are means ± SEM. *p < 0.05; SI organoids: n = 4–18 biological replicates per group; gnotobiotic study: n = 8–13 mice per group.