Table 4.
GRADE evidence profile for PICO 2.
| Certainty assessment | № of patients | Effect | Certainty | Importance | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | MT alone | IVT + MT | Relative (95% CI) | Absolute (95% CI) | ||
| Good outcome (mRS 0-2 at 90 days) | ||||||||||||
| 2 | observational studies49,50 | not serious | not serious | not serious | not serious a | none | 121/311 (38.9%) | 352/703 (50.1%) | OR 0.63 (0.48 to 0.83) | 114 fewer per 1 000 (from 176 fewer to 46 fewer) | ⊕⊕○○ Low | CRITICAL |
| Excellent outcome (mRS 0–1 at 90 days) | ||||||||||||
| 2 | observational studies46,49 | not serious | not serious | not serious | not serious a | none | 48/341 (14.1%) | 111/449 (24.7%) | OR 0.42 (0.16 to 1.09) | 126 fewer per 1 000 (from 197 fewer to 16 more) | ⊕⊕○○ Low | CRITICAL |
| Reduced disability (≥1-point reduction across all mRS-scores at 90 days) - common OR, adjusted analysis | ||||||||||||
| 1 | observational study 49 | not serious | not serious | not serious | serious a | strong association | cOR 0.22 (0.07 to 0.69) | -- per 1 000 (from -- to --) | ⊕⊕○○ Low | CRITICAL | ||
| All-cause mortality at 90 days | ||||||||||||
| 2 | observational studies46,49 | not serious | not serious | not serious | not serious a | none | 90/341 (26.4%) | 107/449 (23.8%) | OR 1.42 (0.59 to 3.44) | 69 more per 1 000 (from 82 fewer to 280 more) | ⊕⊕○○ Low | CRITICAL |
| Symptomatic intracranial haemorrhage | ||||||||||||
| 1 | observational study 49 | not serious | not serious | not serious | very serious a | none | 1/21 (4.8%) | 5/55 (9.1%) | OR 0.50 (0.06 to 4.55) | 43 fewer per 1 000 (from 85 fewer to 222 more) | ⊕○○○ Very low | CRITICAL |
aExtremely small number of events
CI: confidence interval; OR: odds ratio