Table 2.
Patient characteristics of OAC-related ICHs from 2007–2009 and 2017–2019.
| N | OAC-ICH 2007–2009 | OAC-ICH 2017–2019 | p value | |
|---|---|---|---|---|
| N | 289 | 168 | 121 | |
| Sex, men (%) | 88 (52.4) | 60 (49.6) | .639 | |
| Age, median in y [IQR] | 79.1 [72.6–84.2] | 80.2 [72.7–86.4] | .209 | |
| Prior ICH (%) | 288 | 16 (9.6) | 4 (3.3) | .039 |
| VKA-related ICH (%) | 168 | 70 | <.001 | |
| DOAC-related ICH | 0 | 51 | <.001 | |
| Antiplatelet therapy (%) | 14 (8.3) | 3 (2.5) | .037 | |
| Hypertension (%) | 285 | 148 (90.2) | 91 (75.2) | .001 |
| Diabetes mellitus (%) | 283 | 37 (22.8) | 24 (19.8) | .543 |
| Hypercholesterolemia (%) | 284 | 83 (50.9) | 63 (52.1) | .848 |
| Current smoking (%) | 206 | 21 (19.8) | 18 (18.0) | .740 |
| GCS ≤ 8 (%) | 288 | 46 (27.4) | 17 (14.2) | .007 |
| ICH location (%) | ||||
| Lobar | 70 (41.7) | 45 (37.2) | ||
| Deep lobar | 63 (37.5) | 58 (47.9) | .056 | |
| Infratentorial | 35 (14.3) | 16 (10.7) | ||
| Multifocal | 0 | 2 (1.7) | ||
| ICH volume, median in cc [IQR] | 285 | 17.8 [5.2–62.0] | 13.3 [3.9–32.6] | .106 |
| Intraventricular extension (%) | 91 (54.2) | 45 (37.8) | .004 | |
| Hospital mortality (%) | 92 (54.8) | 47 (38.9) | .008 |
ap value for the difference between All ICHs 2007–2009 and All ICHs 2017–2019.
Abbreviations: ICH - intracerebral hemorrhage; OAC-ICH - oral anticoagulant-related ICH, N - number of OAC-ICH cases; y - years; IQR - interquartile range; VKA-related ICH - Vitamin K-related intracerebral hemorrhage; DOAC-related ICH - Direct Oral Anticoagulant-related intracerebral hemorrhage, GCS-score - Glasgow Coma Scale-score; cc - cubic centimeter.