TABLE 4.

Determinants of EC cause‐specific survival for ECSPs with first primary BC and CRC, Florida 2005–2016

Prognostic factors	HR (95% CI)	p‐value
Age category
15–44 (n = 23)	REF
45–54 (n = 168)	1.15 (0.14–9.40)	0.894
55–64 (n = 413)	1.29 (0.17–9.54)	0.806
65–74 (n = 557)	1.51 (0.21–11.08)	0.686
75+ (n = 620)	2.50 (0.34–18.18)	0.365
Race/ethnicity
White (n = 1355)	REF
Black (n = 178)	0.89 (0.56–1.42)	0.629
Hispanic (n = 218)	1.23 (0.80–1.90)	0.339
API (n = 21)	0.81 (0.10–6.49)	0.842
Other (n = 9)	2.01 (0.62–6.48)	0.245
Histology
Type I
Low‐grade endometrioid (n = 829)	REF
Type II
All histologies combined (n = 730)	5.95 (3.70–9.56)	<0.0001
High‐grade endometrioid (n = 219)	4.12 (2.31–7.34)	<0.0001
Carcinosarcoma (n = 173)	11.39 (6.68–19.41)	<0.0001
Clear cell (n = 39)	5.47 (2.44–12.25)	<0.0001
Mixed (n = 91)	5.71 (2.89–11.25)	<0.0001
Serous (n = 208)	4.93 (2.80–8.68)	<0.0001
Other (n = 222)	2.86 (1.54–5.31)	0.0008
ECSP stage
Localized (n = 1072)	REF
Regional (n = 415)	2.60 (1.77–3.83)	<0.0001
Distant (n = 129)	6.47 (4.11–10.19)	<0.0001
Unknown (n = 165)	6.22 (3.65–10.61)	<0.0001
First primary cancer site
Breast (n = 1422)	REF
Colorectal (n = 359)	1.47 (1.04–2.06)	0.028
First primary cancer site stage
Localized (n = 775)	REF
Regional (n = 368)	0.76 (0.54–1.09)	0.133
Distant (n = 50)	0.74 (0.30–1.88)	0.531
Unknown (n = 588)	1.27 (0.76–2.12)	0.369

Abbreviations: BC, breast cancer; EC, endometrial cancer; ECSP, endometrial cancer as a second primary; HR, hazard ratio.