Extended Data Fig. 6 |. Gain and loss genomic instability (GI) burden in European Americans (AAs) and European Americans (EAs) in 23 cancer types from The Cancer Genome Atlas (TCGA).

a, Somatic copy number alteration (SCNA)-gain and b SCNA-loss based GI are quantified and presented stratified by genetic ancestry for 23 cancer types in TCGA where sample size for each cancer type is provided on the x-axis. First, cancer types are categorized by cell type or tissue of origin, if possible, where defined groups are pan-squamous (squamous cell derived tumors), pan-adeno (glandular structures in epithelial tissue derived tumors), pan-kidney (tumors originating in the kidney), and rest (referring to cancer types that cannot be categorized and includes LAML, THYM, GBM, LGG, SARC, BRCA, LIHC, OV, TCGT, THCA and UCEC; Refer here for reference to cancer types: https/gdc.cancer.gov/resources-tcga-users/tcga-code-tables/tcga-study-abbreviations). Second, additional categorization was performed based on tissue type (where solid is derived from solid tumors and neural-crest and Hema & Lymph—hematologic and lymphatic tumors). A two-sided Wilcox Rank-sum test has been performed within each cancer type and significance before multiple testing correction is provided. Here, in the box plot, the center line denotes the median, the box indicates the interquartile range and the black line represents the rest of the distribution, except for points that are determined to be “outliers”, 1.5 times the interquartile range.