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. 2022 Mar 1;12:842418. doi: 10.3389/fonc.2022.842418

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Copyright © 2022 Schneider, Winkler, Kell, Pfaffl, Atkinson and Moertl

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GRP78 expression and outcome in HNSCC patients. (A, B) DEA shows increased GRP78 gene expression in HNSCC tumor tissue (n = 500) in comparison to the non-cancerous tissue samples (n = 44). Data was retrieved from the TCGA database. (B) Comparison of GRP78 expression in paired tumor and non-cancerous tissue samples (n = 43 for both). (C) Kaplan-Meier (KM) survival analysis of HNSCC patients showing decreased survival associated with high GRP78 expression. Survival analysis was evaluated with log-rank test (p = 0.0165).