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. 2022 Mar 1;12:842418. doi: 10.3389/fonc.2022.842418

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Copyright © 2022 Schneider, Winkler, Kell, Pfaffl, Atkinson and Moertl

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased migration of HNSCC cells after overexpression of GRP78. (A–D) Cell migration analysis (gap filling) of GFP-expressing BHY (A, B) and FaDu (C, D) cells. Both cell lines show an increase in migration after overexpression of GRP78 in comparison to control. Cells were transfected with GRP78 plasmid (pGRP78) 72 h prior to migration analysis. Cells transfected with an empty vector (pcDNA) were used as control (n = 4, Two-way RM ANOVA).