Table 1.
Patient Characteristics
| Characteristic | Healthy Controls (n = 7) | Inactive Carriers (n = 21) | P Value |
|---|---|---|---|
| Male sex, % (no.) | 57 (4) | 47 (10) | NSa |
| Race/ethnicity | |||
| White | 6 | 7 | NA |
| African | 0 | 5 | |
| Asian | 0 | 5 | |
| Other | 1 | 4 | |
| Age, median (IQR), y | 51 (27–55) | 36 (28–42) | NSb |
| Laboratory values, median (IQR) | |||
| ALT, IU/mL | 28 (23–40) | 27 (29–33) | NSb |
| AST, IU/mL | 25 (23–04) | 24 (19–30) | NSb |
| Prothrombin time, sc | NA | 8 (10.3–12.1) | NA |
| Total bilirubin, µmol/Lc | NA | 9 (8–11.4) | NA |
| HBV DNA, median (maximum), log IU/mLd | NA | 2.3 (3.7) | NA |
| HBeAg negative | NA | 21 | NA |
| Anti-HbeAg positive | NA | 21 | NA |
| Serum HBsAg, median (IQR), IU/mL | NA | 1750 (555–9475) | NA |
| HBsAg-positive liver cells, % (IQR)e | NA | 30 (7–69) | NA |
| HBV genotype | NA | A in 4, B in 2, C in 2, D in 9, E in 1; ND in 3 | NA |
| Fibrosis score <F2 | 5 (ND in 2) | 21 | NA |
| HAI score ≤5 | ND | 21 | NA |
| NASH | |||
| No | 7 | 20 | NSa |
| Yes | 0 | 1 | |
| Steatosis | 7/0 | ||
| No | 7 | 17 | NSa |
| Yes | 0 | 4 |
Abbreviations: ALT, alanine transferase; AST, aspartate aminotransferase; HAI, hepatic activity index; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; IQR, interquartile range; NA, not applicable; NASH, non-alcoholic steatohepatitis; ND, not determined; NS, not significant.
a P values calculated with Fisher exact test.
b P values calculated with unpaired Mann-Whitney test.
cDetermined in 18 of 21 inactive carriers.
dUndetectable HBV DNA in 10 of 21 inactive carriers.
eDetermined in 16 of 21 inactive carriers.