TABLE 2.

Mean vancomycin concentrations in serum and CSF during the first 12 h of treatment in rabbits receiving a single dose of dexamethasone

Regimen	Groupa	Compartment	Mean ± SD concn (μg/ml) at the following time intervals (h) after administration of initial  doseb:
			1	2	3	4	6	9	12
Vancomycin at 20 mg/kg every 6 h + DXMc at 1 mg/kg	1 (7)	Serum	22.8 ± 3.3	14.7 ± 7.1	7.4 ± 2.2	5.9 ± 3.3	3.9 ± 3.5
		CSF	0.8 ± 0.5	1.0 ± 0.6	1.1 ± 0.7	1.1 ± 0.8	1.2 ± 1.0
	2 (7)	Serum					1.4 ± 1.2	9.2 ± 6.4	4.1 ± 4.8
		CSF					0.7 ± 0.6	1.1 ± 0.8	1.1 ± 0.8
Vancomycin at 40 mg/kg every 12 h + DXM at 1 mg/kg	1 (4)	Serum	47.4 ± 9.5	26.5 ± 3.3	16.4 ± 5.8	13.2 ± 5.2	7.2 ± 3.1
		CSF	1.8 ± 1.6	2.2 ± 2.1	2.0 ± 1.7	1.8 ± 1.3	1.4 ± 1.3
	2 (6)	Serum					3.6 ± 4.2	1.2 ± 1.7	0.7 ± 0.9
		CSF					1.0 ± 0.6	0.5 ± 0.1	0.5 ± 0.2

^aAnimals received either one (40-mg/kg) or two (20-mg/kg) doses of vancomycin and received one (1-mg/kg) dose of dexamethasone at the initiation of therapy. CSF and blood were obtained at 1, 2, 3, 4, and 6 h after administration of the initial dose for group 1 and at 6, 9, and 12 h after the administration of the initial dose for group 2. Numbers in parentheses represent the numbers of animals per group for each treatment regimen. 

^bSee Materials and Methods for methods of calculation of mean values. 

^cDXM, dexamethasone.