Figure 3.

Schematic illustration of JX06‐NPs downregulating the expression of PDK1 combined with Met for targeting cancer plasticity and reprogramming the glucose metabolism for synergistic antitumor effect. A reduction‐sensitive polymer (P1) was adopted to encapsulate JX06 to form JX06‐NPs. JX06‐NPs were then intravenously injected into mice^EC+/dia+, and Met was administered orally. Met could not only reduce the blood glucose levels, but also inhibit mitochondrial complex I and oxidative phosphorylation. Thereafter, JX06‐NPs could release JX06 after entering cancer cells, downregulating the expression of PDK1, which subsequently inhibits glycolysis. Therefore, JX06‐NPs combined with Met could accelerate the apoptosis of EC and inhibit tumor growth.