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. 2021 Oct 19;29(4):686–693. doi: 10.1093/jamia/ocab221

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© The Author(s) 2021. Published by Oxford University Press on behalf of the American Medical Informatics Association.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Overall scheme of the Data Trust, showing data sources flowing into the Data Trust, and research workflows for using the data (solid lines represent ongoing routine data flows and dashed lines represent data sources under development, but nonetheless used for specific studies in the past). A robust honest broker system enables patient re-identification for IRB approved protocols to enable participant recruitment. PROs: Patient-Reported Outcomes; ETL: extract, transform, and load; IDs: identifiers; IRB: Institutional Review Board.