FIGURE 3.

Hyper-phosphorylated NfH immunolabeling in a young adult and older persons with SVD or with AD. (A) Young adult (male, age 20). Sparse axonal pNfH labeling is seen in subcortical white matter. (B) Older person with small vessel disease. The small arterial vessel exhibits fibrotic thickening, characteristic of SVD. Strongly positive axons and axonal bulbs are seen around the vessel. (C) Older person with severe Alzheimer disease pathology (Braak stage VI). Axonal labeling is widespread but lacks vasculocentric orientation. Scale bars: 100 μm.