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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Genesis. 2021 Sep 3;59(10):e23447. doi: 10.1002/dvg.23447

Figure 6: Hmgn1 knockdown affects neural crest streams formation.

Figure 6:

(A) Phenotype of CoMO (20 ng) and Hmgn1MO (20 ng) injected embryos at NF stage 23–25 analyzed for sox10 and twist1 expression. The red brackets indicate the extent of dorso-ventral extension of neural crest streams in control and MO-injected sides. (B) Higher magnification of an embryo stained with sox10 showing the position of the three neural crest streams. Lateral view, dorsal to top, anterior to left. (C-D) Graph plotting the distance migrated by neural crest cells in stream 1, 2 and 3 of CoMO- and Hmgn1MO-injected embryos stained by sox10 (C) or twist1 (D). A similar number of embryos were analyzed for each gene (CoMO, n=21 and Hmgn1MO, n=30). Brown-Forsyth and welch ANOVA test, with multiple comparisons test (Dunnett) with individual variances computed for each comparison. *, p=0.0141; **, p=0.0013; ***, p=0.0003; ****, p<0.0001; ns: not significant.