Table 2.
Incidence of tNSAID-Induced Serious GI Complications in Chronic tNSAID Users by Risk Grade and Number of Risk Factors
| Population | Number of Events | Incidence Proportion | Incidence Ratea | |||
|---|---|---|---|---|---|---|
| % | p-value | 100 Person-Years (95% CI) | p-value | |||
| High risk group (N=14,262) | PPI (N=9,440) | 15 | 0.16 | 0.02 | 0.78 (0.44, 1.29) | < 0.01 |
| Rebamipide (N=4,822) | 17 | 0.35 | 2.13 (1.24, 3.41) | |||
| Moderate risk group with 2 risk factors (N=26,724) | PPI (N=13,362) | 15 | 0.11 | 0.09 | 0.58 (0.32, 0.95) | 0.03 |
| Rebamipide (N=13,362) | 26 | 0.19 | 1.17 (0.77, 1.72) | |||
| Elderly patients without risk factors (N=21,034) | PPI (N=10,517) | 14 | 0.13 | 0.30 | 0.73 (0.40, 1.23) | 0.40 |
| Rebamipide (N=10,517) | 9 | 0.09 | 0.51 (0.23, 0.97) | |||
Note: aIncidence rate per 100 person-years.
Abbreviations: CI, confidence interval; GI, gastrointestinal; PPI, proton-pump inhibitor; tNSAID, traditional nonsteroidal anti-inflammatory drug.