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Coronaviridae (CoV) TMD have larger (a) ASA and (b) are more hydrophobic as compared to other viruses. Corresponding values for TMDs of human membrane proteins in ER, Golgi and plasma membrane (PM) are shown in the lower panel. The values for Coronaviridae differ significantly from all others: (Wilcoxon test) p-values < 0.001 in all cases, except for Coronaviridae and Golgi ASA (p < 0.02).
