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. 2022 Feb 22;8(3):557–573. doi: 10.1021/acsinfecdis.1c00570

Figure 6.

Figure 6

Activity in a DHP-1 model of murine TB. (a) Structures of β-lactams tested in a dehydropeptidase-1 (DHP-1) knockout mouse model of acute TB. The structure of TBBL-0000316 is in Figure 5d. (b) Compounds were provided to infected mice between days 9 and 15 of the infection and CFU was enumerated by plating lung homogenates on 7H11-OADC agar plates supplemented with 0.4% activated charcoal to prevent drug carryover. Unless otherwise noted, β-lactams were dosed BID at 50 mg/kg SC and paired with clavulanate-dosed BID at 100 mg/kg PO. P-values were obtained by ANOVA analysis (Dunnett’s post-test, GraphPad software) comparing treatments with test agents with the day 16 CFU counts from untreated mice. The fates of individual mice are summarized in Table S9. *p < 0.01–0.05, **p = 0.001–0.01.