Table 2.
Randomized Controlled Trials of PRP in Male Androgenic Alopecia
| Author, Year | Number of Patients | Platelet Rich Plasma Preparation | Treatment Regimen | Results |
|---|---|---|---|---|
| Qu Q et al 202142 | N= 52 (32M 20F) | - Double spin - without PLT activator - PLT count: NR |
3 injections (monthly) with PRP VS saline (half-head study) | 6 months: significant increase in hair density, hair thickness and anagen hair ratio in PRP compared to placebo |
| Pakhomova EE et al 202044 | N= 69 M | - Double spin - with PLT activator - PLT count: 882.5 ± 143.62 × 109/L |
1. Topical minoxidil 5% (23) 2. 4 injections (monthly) with PRP (23) 3. 4 injections (monthly) with PRP + topical minoxidil 5% (23) |
4 months: significant increase in hair density and hair thickness in PRP + topical minoxidil group followed by PRP monotherapy group |
| Shapiro et al 202045 | N= 35 (18M17F) | - Single spin - without PLT activator - PLT count: NR |
3 injections (monthly) with PRP VS saline (two 7.6-cm × 7.6-cm squares, split head study) | 3 months: significant increase in hair density and hair thickness in PRP compared to baseline, but not significant increase compared to placebo |
| Dicle et al 202046 | N= 30 M | - Single spin - with PLT activator - PLT count: NR |
3 injections (monthly) with PRP first (10) VS saline first (15) (first half of crossover trial) | 4 months: significant increase in hair density in the group that received placebo and subsequently received PRP injections (after wash- out period) |
| Singh et al 202047 | N= 80 M | - Double spin - with PLT activator - PLT count: 4.2-fold higher than whole blood |
1.Topical minoxidil 5% + 3 injections (monthly) with saline (20) 2.Topical minoxidil 5% + 3 injections (monthly) with PRP (20) 3.Topical placebo + 3 injections (monthly) with saline (20) 4.Topical placebo + 3 injections (monthly) with PRP (20) |
5 months: significant increase in hair density in PRP + topical minoxidil group followed by PRP + topical placebo group |
| Rodrigues et al 201948 | N= 26 M | - Double spin - with PLT activator - PLT count: 1200×106 /µL |
4 injections (every 15 days) with PRP (15) VS saline (11) | 3 months: significant increase in hair density and percentage of anagen hairs in PRP group compared to placebo group |
| Gentile et al 201731 | N= 18 M | - Single spin - without PLT activator - PLT count: 5 - fold higher than whole blood |
3 injections (monthly) with PRP VS saline (half-head study) |
3 months: significant increase in hair density in PRP compared to placebo |
Abbreviations: PLT, platelet; NR, not reported.