Table 3.

Randomized Controlled Trials of PRP in Female Pattern Hair Loss

Author, Year	Number of Patients	Platelet Rich Plasma Preparation	Treatment Regimen	Results
Dubin DP et al 202054	N= 30F	- Single spin - without PLT activator - PLT count: NR	3 injections (monthly) with PRP (14) VS saline (14; 2- loss follow up)	6 months: significant increase in hair density and hair thickness in PRP group compared to placebo group
Bruce et al 201955	N= 20F	- Double spin - with PLT activator - PLT count: NR	3 injections (monthly) with PRP first (9) VS minoxidil foam first (9) (first half of crossover trial)	4 months: significant increase in vellus hair density and hair count in both groups compared to baseline
Tawfik and Osman, 201856	N= 30F	- Double spin - with PLT activator - PLT count: NR	4 injections (weekly) with PRP VS saline (half-head study)	6 months: significant increase in hair density and hair thickness in PRP compared to placebo
Lee et al 201557	N= 40F	- Single spin - with PLT activator - PLT count: 1,256,950 ± 371,397 cells/μL	Single PRP with 12 sessions of PDRN injections (20) VS 12 sessions of PDRN injections only (20)	3.25 months: combined therapy with PRP induced more hair thickness than PDRN alone

Abbreviations: PLT, platelet; NR, not reported; PDRN, polydeoxyribonucleotide.