Table 4.
Randomized Controlled Trials of PRP in Alopecia Areata
| Author, Year | Number of Patients | Platelet Rich Plasma Preparation | Treatment Regimen | Results |
|---|---|---|---|---|
| Fawzy MM et al 202162 | N= 31 (23M8F) | - Single spin - without PLT activator - PLT count: 750,000–1,000,000/μL. |
3 injections (monthly) with 1.PRP (17) 2.Triamcinolone acetonide 40 mg/mL (14) |
4 months: significant reduction in SALT score in both groups compared to baseline |
| Balakrishnan A et al 202063 | N= 40 (22M18F) | - Double spin - without PLT activator - PLT count: NR |
3 injections (monthly) with 1.PRP (16) 2.Triamcinolone acetonide 10 mg/mL (16) |
3 months: significant improvement in clinical symptoms in both groups, but there was no significant difference between these two groups |
| Hegde P et al 202064 | N= 50 | - Double spin - without PLT activator - PLT count: NR |
3 injections (monthly) Right side of the scalp with 1.PRP (25) 2.Triamcinolone acetonide 10 mg/mL (25) Left side of the scalp with saline |
5 months: SALT score showed statistically significant improvement from baseline in both groups. Steroid group showed the most hair regrowth, followed by PRP group |
| Kapoor P et al 202068 | N= 40 | - Single spin - without PLT activator - PLT count: 3.5-fold higher than whole blood |
4 injections (every 3 weeks) with 1.PRP (20) 2.Triamcinolone acetonide 10 mg/mL (20) |
6 months: significant reduction in SALT score in triamcinolone group compared to PRP group |
| Albalat et al 201965 | N= 80 (68M12F) | - Double spin - with PLT activator - PLT count: NR |
3‐5 injections (every 2 weeks) with 1.PRP (40) 2.Triamcinolone acetonide 5 mg/mL (40) |
6 months: significant increase in hair regrowth and reduction of dystrophic hair in both groups, but there was no significant difference between these two groups |
| Agrawal P et al 201867 | N= 30 | - Double spin - with PLT activator - PLT count: NR |
3 injections (monthly) with 1.PRP (15) 2.Triamcinolone acetonide 5 mg/mL (15) |
6 months: significant increase in the percentage of hair regrowth in triamcinolone group compared to PRP group |
Abbreviations: PLT, platelet; NR, not reported; SALT, severity of alopecia tool score.