Fig. 4.

Structural comparisons between CCHFV Gc and other bunyavirual Gc. A Superposition of CCHFV Gc onto RVFV Gc (PDB ID: 6GET) is presented as stereo pairs. The CCHFV Gc monomer is colored as in Fig. 3B whereas RVFV Gc is colored gray. All three domains of CCHFV and RVFV can be roughly superpositioned. B Superposition of CCHFV Gc onto HTNV Gc (gray, PDB ID: 5LJZ). Domains I and II are superimposable, whereas domain III is on the opposite side. C Pairwise Gc sequence alignment of CCHFV and RVFV. The secondary structural elements of CCHFV Gc are shown at the top of sequences corresponding to the ribbon diagrams presented in Fig. 3B. In addition, two elongated β strands spanning domains I and II are divide into E₀/a and e/F₀ (corresponding to RVFV). The fusion loop of RVFV is indicated by an orange line. The disulfide bonds of CCHFV and RVFV are labeled with green letters at the top and bottom of the sequences, respectively. Conserved or similar amino acids are highlighted in light blue border, whereas fully conserved amino acids are highlighted in red. CCHFV, Crimean-Congo hemorrhagic fever virus; RVFV, Rift Valley fever virus.