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. 2022 Mar 10;9:157–170. doi: 10.2147/JHC.S353956

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© 2022 Huang et al.

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Two patients with hepatocellular carcinoma (HCC) who achieved complete response according to modified response evaluation criteria in solid tumors during second-line treatment with regorafenib combined with sintilimab (rego-sintilimab). (A) Case 1, a 52-year-old male who sequentially underwent liver resection, transarterial chemoembolization, and sorafenib treatment. The arterial phase CT image 3 days prior to rego-sintilimab treatment showed multiple HCC nodules in the right liver lobe. (B) Arterial phase CT imaging from case 1 at 17 weeks after initiation of rego-sintilimab showed that enhancement of all HCC nodules in the right liver lobe disappeared. (C) Case 2, a 48-year-old female who sequentially underwent transarterial chemoembolization and sorafenib treatment. The arterial phase CT image 5 days prior to rego-sintilimab treatment showed a large HCC mass with inhomogeneous enhancement at segment 4 (arrow). (D) Arterial phase CT imaging of case 2 at 8 months after initiation of rego-sintilimab showed significant shrinkage and no enhancement of the HCC (arrow).