Table 2.

Analysis of RAI2 expression status with OS or RFS in colorectal cancer patients by Cox regression analysis.

Variables	OS				RFS
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95%CI)	P	HR(95%CI)	P	HR (95%CI)	P	HR(95%CI)	P
RAI2 expression	0.644	0.010*	0.683	0.027*	0.645	0.011*	0.671	0.022*
high vs low	(0.462-0.898)		(0.488-0.957)		(0.460-0.904)		(0.477-0.945)
Age (year)	0.619	0.005**	0.560	0.001**	0.853	0.348	0.780	0.158
>60 vs ≤ 60	(0.444-0.863)		(0.397-0.789)		(0.612-1.189)		(0.553-1.101)
Gender	1.021	0.900	0.950	0.764	1.010	0.953	0.950	0.767
Female vs Male	(0.735-1.420)		(0.678-1.331)		(0.724-1.409)		(0.675-1.337)
Tumor location	1.026	0.900	1.174	0.467	1.034	0.872	1.250	0.322
distal colon or rectum vs proximal colon	(0.686-1.535)		(0.762-1.810)		(0.687-1.556)		(0.804-1.943)
Tumor size	0.808	0.268	0.729	0.118	0.796	0.244	0.727	0.120
≤5 cm vs >5 cm	(0.554-1.178)		(0.490-1.083)		(0.543-1.168)		(0.486-1.087)
Differentiation	1.055	0.765	1.091	0.630	0.998	0.990	1.038	0.839
Low vs High/middle	(0.744-1.495)		(0.766-1.553)		(0.700-1.423)		(0.725-1.486)
TNM-stage	2.182	0.000***	2.439	0.000***	2.067	0.000***	2.237	0.000***
III/IV vs I/II	(1.558-3.055)		(1.708-3.483)		(1.464-2.918)		(1.550-3.228)
Pathologic N stage	0.996	0.989	1.213	0.541	1.003	0.992	1.239	0.500
N1-2 vs N0	(0.538-1.843)		(0.653-2.253)		(0.542-1.856)		(0.665-2.311)
Intravascular cancerous embolus	1.302	0.255	1.061	0.805	1.044	0.863	0.884	0.633
Yes vs No	(0.827-2.051)		(0.665-1.693)		(0.637-1.713)		(0.533-1.467)

*P <0.05, **P < 0.01, ***P < 0.001.