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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2021 Mar 26;85:100967. doi: 10.1016/j.preteyeres.2021.100967

Figure 1.

Figure 1.

Kinetics of live MSCs in the lung and 7 other tissues after IV infusion of 2 × 106 human MSCs into mice.

The kinetics and redistribution of human BM-derived MSCs after IV administration into mice were evaluated by a real-time PCR assay for human Alu sequence and GAPDH. About 85% of the human BM-derived MSCs were initially trapped in the lung within a few minutes after IV infusion and disappeared with a half-life of 24 hours. The cells did not appear in any significant numbers in other tissues, 0.04% of the infused MSCs having been recovered after 48 hours and 0.01% after 96 hours.

Reprinted with permission from Cell Stem Cell. Lee et al., 2009. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 5, 54–63. Copyright © 2009 Elsevier Inc.