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Effects of topically applied MSC-EVs on corneal epithelial regeneration.
Topical instillation of EVs derived from human MSCs markedly facilitated corneal epithelial healing in BALB/c mice following mechanical removal of corneal epithelium, as evaluated by fluorescein vital dye staining. The transcript levels of inflammatory cytokines (IL-1β and IL-6) in the cornea also were decreased by the MSC-EVs.
