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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2021 Mar 26;85:100967. doi: 10.1016/j.preteyeres.2021.100967

Figure 5.

Figure 5.

Effects of MSCs on naturally-occurring canine KCS.

Allogeneic AT-derived MSCs were injected into the dorsal LG and the third eyelid LG in dogs with naturally occurring KCS. Prior to MSC transplantation, there was ocular discharge, conjunctival hyperemia, corneal opacity and vascularization, as well as Schirmer test results of 2 mm/min, all of which are clinical signs of KCS (A). MSCs dramatically reduced clinical signs of KCS both in the short term (28 days after MSC treatment, A’) and in the long term (12 months after MSC treatment, A”).

Reprinted with permission from Cell Medicine. Bittencourt et al., 2016. Allogeneic Mesenchymal Stem Cell Transplantation in Dogs With Keratoconjunctivitis Sicca. Cell Med. 8, 63–77. Copyright © 2016 Cognizant, LLC.