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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2021 Mar 26;85:100967. doi: 10.1016/j.preteyeres.2021.100967

Figure 6.

Figure 6.

Effects of MSCs on EAU.

Human BM-derived MSCs or vehicle (Hank’s balanced salt solution, HBSS) were administered into C57BL/6 (H-2b) mice either intraperitoneally or intravenously immediately after EAU induction via IRBP immunization. Both IFN-γ+CD4+ Th1 cells and IL-17+CD4+ Th17 cells were significantly reduced in DLNs by MSC treatment. Accordingly, the transcript levels of IFN-γ and IL-17A in the eye were decreased by MSCs, and the retinal architecture was preserved with a smaller number of TUNEL+ apoptotic cells, all of which indicate the protection against EAU.

Reprinted with permission from The Journal of Immunology. Lee et al. 2015. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells. J. Immunol. 194, 3634–3645.

Copyright © 2015 The American Association of Immunologists, Inc. and from Mediators of Inflammation. Oh et al., 2014. Intraperitoneal infusion of mesenchymal stem/stromal cells prevents experimental autoimmune uveitis in mice. Mediators Inflamm. 2014, 624640.