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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Prog Retin Eye Res. 2021 Mar 26;85:100967. doi: 10.1016/j.preteyeres.2021.100967

Figure 7.

Figure 7.

MSCs increased monocytic MDSCs in DLNs and peripheral blood in mice with EAU.

One day after EAU induction and MSC IV administration, the increase of IL-10-expressing MHC IIloLy6G−Ly6ChiCD11b+ cells was noted in DLNs and peripheral blood in mice. Also, there were up to 80- and 400-fold increases in iNOS and Arg1, the molecules known to mediate the immunosuppressive functions of MDSCs, in DLNs of the MSC-treated mice.

Reprinted with permission from The Journal of Immunology. Lee et al. 2015. Mesenchymal stem/stromal cells protect against autoimmunity via CCL2-dependent recruitment of myeloid-derived suppressor cells. J. Immunol. 194, 3634–3645. Copyright © 2015 The American Association of Immunologists, Inc.