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. Author manuscript; available in PMC: 2022 Jun 25.
Published in final edited form as: Circ Res. 2021 Jun 24;129(1):195–215. doi: 10.1161/CIRCRESAHA.121.318174

Figure 5. Progression of CCM Lesion Pathogenesis.

Figure 5.

The pathogenesis of CCMs begins with an inherited or somatic mutation, followed by somatic mutations resulting in lesion genesis and growth. The natural history of CCM disease is thought to lead to five clinically relevant outcomes (1) lesion stabilization, (2) lesion regression, (3) increased lesion burden, (4) symptomatic hemorrhage (SH), and/or (5) lesional growth (shown from top to bottom). CASH, Cavernous Angioma with Symptomatic Hemorrhage.