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. 2022 Feb 28;12:824704. doi: 10.3389/fonc.2022.824704

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Copyright © 2022 Daneels, Rosskamp, Macq, Saadoon, De Geyndt, Offner and Poirel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Observed survival after incomplete R-CHOP. These Kaplan–Meier curves show the observed survival from diagnosis of patients receiving first-line treatment with incomplete R-CHOP (< 6 cycles or < 4 cycles if Ann Arbor stage = I, or CHOP without R) grouped by refractory status (start of any second-line treatment within 12 weeks from the end of first-line therapy), number of R-CHOP cycles, and radiotherapy within 12 weeks from the end of the last R-CHOP cycle. Primary refractory cases had the worst survival. The overall survival of incomplete R-CHOP followed by radiotherapy (green curves) was similar to that of full-R-CHOP. Immortal time bias is not taken into account as survival is presented from diagnosis and patients have to survive until the end of a treatment to be categorized as having received this treatment. Colored areas represent the 95% confidence intervals.