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. 2022 Feb 28;12:824704. doi: 10.3389/fonc.2022.824704

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Copyright © 2022 Daneels, Rosskamp, Macq, Saadoon, De Geyndt, Offner and Poirel

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Observed survival after second-line treatment. These Kaplan–Meier curves show the observed survival from the start of second-line treatment grouped by treatment categories. Patients receiving subsequent ASCT and/or AlloSCT are included. Both platinum and non-platinum-containing regimens are associated with a similar but limited long-term overall survival. Palliative and bendamustine-containing regimens provided (nearly) no survival beyond the 1-year mark. Colored areas represent the 95% confidence intervals.