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. 2022 Mar 15;11:17. doi: 10.1186/s40035-022-00291-4

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Motor performance is impaired in TDP-43 mice. a TDP-43 mice (n = 7) performed significantly worse in the rotarod task than their littermate controls (n = 5), which improved over time. Two-way ANOVA revealed a significant interaction between time and genotype (P < 0.0001), and a main effect of genotype with control mice running for significantly longer than TDP-43 mice (P < 0.0001). b Survival plot showing the percentage of mice not clasping at 1, 2 and 3 weeks post-Dox cessation. c The body weight of mice measured on the day of, and every two days after, the cessation of Dox feed. Two-way ANOVA demonstrated a significant interaction between genotype and time (P < 0.0001). Main effects of genotype are indicated by lines with asterisk between genotype symbols in figure legends. Significant results following Šídák’s multiple comparison testing are indicated by asterisk(s) at corresponding time points. *P < 0.05, **P < 0.01, ***P < 0.001