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. 2022 Mar 15;19:44. doi: 10.1186/s12985-022-01779-1

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Oncolytic activity of VG9-IL-24 in vitro. A The proliferation of VG9-EGFP in SMMC-7721 cells and HL-7702 cells. The viral replication was monitored under the fluorescence microscope after infection for 48 h. Bar: 20 μm. B VG9-IL-24 selectively replicated in tumor cells. HCC cells and HL-7702 cells in 12-well plates were infected with 0.1 MOI of VG9-IL-24 and samples were collected at 48 h. Each bar represents the mean ± SD (n = 3)