Table 1.
Comparing xylazine, detomidine, medetomidine on physiological variables (mean ± standard deviation) during laparoscopic embryo (somatic cell nuclear transfer) transferring in 60 does. Animals were assigned to five intravenous groups: control (normal saline, 5 mL); XYL, xylazine (100 μg kg− 1); DET, detomidine (50 μg kg− 1); MED, medetomidine (20 μg kg− 1); and DEX, dexmedetomidine (5 μg kg− 1)
| Varaibles | Groups | Time (minutes) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline | 5 | 10 | 15 | 30 | 45 | 60 | 90 | 120 | ||
| HR (beats minute− 1) | Control | 107 ± 5 | 106 ± 5 | 107 ± 3 | 118 ± 4 † | 118 ± 3 † | 119 ± 3 † | 107 ± 4 | 108 ± 3 | 106 ± 4 |
| XYL | 105 ± 6 | 100 ± 6 *† | 95 ± 5 *† | 90 ± 6 *† | 80 ± 6 *† | 79 ± 4 *† | 81 ± 4 *† | 87 ± 4 *† | 106 ± 5 | |
| DET | 108 ± 3 | 100 ± 2 *† | 97 ± 3 *† | 94 ± 4 *† | 84 ± 4 *† | 82 ± 4 *† | 84 ± 3 *† | 89 ± 2 *† | 107 ± 3 | |
| MED | 103 ± 4 | 98 ± 3 *† | 93 ± 5 *† | 89 ± 4 *† | 81 ± 3 *† | 79 ± 4 *† | 82 ± 3 *† | 87 ± 3 *† | 103 ± 3 | |
| DEX | 107 ± 6 | 100 ± 4 *† | 96 ± 6 *† | 92 ± 5 *† | 82 ± 5 *† | 83 ± 5 *† | 83 ± 4 *† | 87 ± 4 *† | 107 ± 6 | |
|
RR (breaths minute− 1) |
Control | 29 ± 2 | 28 ± 2 | 28 ± 2 | 32 ± 1 † | 32 ± 1 † | 32 ± 1 † | 28 ± 1 | 28 ± 1 | 29 ± 1 |
| XYL | 28 ± 1 | 27 ± 1 | 27 ± 1 | 26 ± 1 *† | 24 ± 1 *† | 23 ± 1 *† | 25 ± 1 *† | 27 ± 1 | 28 ± 1 | |
| DET | 28 ± 2 | 27 ± 2 | 27 ± 2 | 26 ± 2 *† | 24 ± 2 *† | 23 ± 2 *† | 25 ± 1 *† | 27 ± 2 | 28 ± 2 | |
| MED | 29 ± 2 | 28 ± 2 | 28 ± 2 | 27 ± 2 *† | 25 ± 2 *† | 24 ± 2 *† | 25 ± 2 *† | 27 ± 2 | 28 ± 2 | |
| DEX | 29 ± 2 | 28 ± 2 | 28 ± 2 | 27 ± 2 *† | 24 ± 2 *† | 24 ± 2 *† | 25 ± 2 *† | 27 ± 2 | 28 ± 1 | |
| RT (° C) | Control | 38.8 ± 0.2 | 38.8 ± 0.2 | 38.8 ± 0.3 | 38.9 ± 0.2 | 38.6 ± 0.3 | 38.6 ± 0.2 | 38.6 ± 0.2 | 38.7 ± 0.1 | 38.6 ± 0.1 |
| XYL | 38.7 ± 0.4 | 38.6 ± 0.1 | 38.7 ± 0.2 | 38.8 ± 0.2 | 38.8 ± 0.2 | 38.6 ± 0.2 | 38.7 ± 0.2 | 38.5 ± 0.2 | 38.8 ± 0.2 | |
| DET | 38.6 ± 0.3 | 38.7 ± 0.2 | 38.6 ± 0.2 | 38.6 ± 0.2 | 38.8 ± 0.2 | 38.8 ± 0.3 | 38.8 ± 0.3 | 37.8 ± 0.3 | 38.6 ± 0.2 | |
| MED | 38.8 ± 0.1 | 38.8 ± 0.1 | 38.7 ± 0.2 | 38.7 ± 0.2 | 38.6 ± 0.2 | 38.6 ± 0.2 | 37.9 ± 0.3 | 37.8 ± 0.3 | 38.7 ± 0.2 | |
| DEX | 38.6 ± 0.2 | 38.7 ± 0.1 | 38.6 ± 0.2 | 38.7 ± 0.2 | 38.7 ± 0.1 | 38.7 ± 0.3 | 37.7 ± 0.3 | 38.7 ± 0.2 | 38.6 ± 0.3 | |
| Ruminal motility (contraction minutes− 1) | Control | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| XYL | 2 | 1 *† | 0 *† | 0 *† | 0 *† | 0 *† | 0 *† | 1 *† | 1 *† | |
| DET | 2 | 1 *† | 0 *† | 0 *† | 0 *† | 0 *† | 0 *† | 1 *† | 1 *† | |
| MED | 2 | 1 *† | 0 *† | 0 *† | 0 *† | 0 *† | 0 *† | 1 *† | 1 *† | |
| DEX | 2 | 1 *† | 0 *† | 0 *† | 0 *† | 0 *† | 0 *† | 1 *† | 1 *† | |
| Cortisol (nmol/l) | Control | 59 ± 11 | – | – | – | – | 80 ± 8 † | – | – | 61 ± 14 |
| XYL | 60 ± 13 | – | – | – | – | 34 ± 6 *† | – | – | 48 ± 4 *† | |
| DET | 63 ± 12 | – | – | – | – | 34 ± 7 *† | – | – | 45 ± 3 *† | |
| MED | 60 ± 13 | – | – | – | – | 36 ± 4 *† | – | – | 46 ± 5 *† | |
| DEX | 63 ± 11 | – | – | – | – | 35 ± 5 *† | – | 44 ± 3 *† | ||
HR Heart rate, RR Respiratory rate, RT Rectal temperature
*Significantly different from control at the same time point (p < 0.05)
† Significantly different from baseline value within the same group (p < 0.05)