Fig. 1.

Schematic illustration of early imaging of pulmonary metastasis of breast cancer by a self-luminescence nanoprobe. A Neutrophil-dependent luminescence imaging of lung micrometastasis of breast cancer based on MPO/H₂O₂-mediated chemiluminescence resonance energy transfer (CRET) using a self-illuminating and neutrophil-targeting nanoprobe (LAD-PGP NPs). B A sketch shows engineering of LAD-PGP NPs composed of a self-luminescent material of luminol-conjugated β-cyclodextrin (LCD, a CRET donor), an aggregation-induced emission compound (PPV, a CRET acceptor), and a neutrophil-targeting unit DSPE-PEG-PGP